Connective tissue growth factor antibodies
AssigneeFibroGen, Inc.
InventorsAl Y. LIN, Thomas B. NEFF, Noelynn A. OLIVER, William R. USINGER, Qingjian WANG, David A. YEOWELL
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Abstract
The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
Claims20
1-101. (canceled)
A method for treating a connective tissue growth factor (CTGF)-associated disorder or condition comprising administering to a subject in need thereof an effective amount of an antibody or fragment thereof, wherein the antibody, or fragment binds to a region of human connective tissue growth factor (CTGF) set forth as amino acids 143 to 154 of SEQ ID NO:2, thereby treating the CTGF-associated disorder or condition.
Dependencies are inferred from the claim text.