ANTIBODIES TO PfGARP KILL PLASMODIUM FALCIPARUM MALARIA PARASITES AND PROTECT AGAINST INFECTION AND SEVERE DISEASE
AssigneeRhode Island Hospital
InventorsJonathan Kurtis, Dipak K. Raj, Alok Das Mohapatra, Jenna Zuromski
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Abstract
Provided herein are methods, compositions and kits for preventing and treating malaria. Also included herein are kits for preventing and treating malaria.
Claims24
An anti-Plasmodium falciparum (P. falciparum) PfGARP antibody comprising a heavy chain variable region comprising the amino acid sequences set forth in SEQ ID NO:
- 1 (complementary determining region (CDR)1), SEQ ID NO:
- 2 (CDR2), and/or SEQ ID NO:
- 3 (CDR3);
- and/or a light chain variable region comprising the amino acid sequences set forth in SEQ ID NO:
- 4 (CDR1), SEQ ID NO:
- 5 (CDR2), and/or SEQ ID NO:
- 6 (CDR3).
A P. falciparum PfGARP antibody comprising one or more sequences, wherein the one or more sequences have at least 50% identity to SEQ ID NO:
- 1, 2, 3, 4, 5, and/or 6 and further comprise a binding specificity to an epitope of PfGARP comprising or consisting of the amino acid sequence, EDKDGVEI (SEQ ID NO:
- 1).
A method of inducing loss of food vacuole integrity of a Plasmodium sp. organism, comprising contacting the organism with a non-small molecule compound or inhibiting trophozoite development of a Plasmodium sp. organism, comprising contacting the organism with a non-small molecule compound.
A method of activating Programmed Cell Death of a Plasmodium sp. organism, comprising contacting the organism with a PfGARP-binding compound.
Dependencies are inferred from the claim text.