Transthyretin antibodies and uses thereof
AssigneeMor Research Applications Ltd.
InventorsMichael FASSLER, Jacob GEORGE
Life of this patent
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Abstract
The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human transthyretin (TTR). The anti-TTR antibodies or antigen-binding fragments thereof are useful, for example, in detecting TTR and in treating TTR amyloidosis in a subject.
Claims81
An antibody or antigen-binding fragment thereof capable of binding human transthyretin (TTR), wherein the antibody or antigen-binding fragment thereof comprises a complementary determining region (CDR) H1 comprising the amino acid sequence set forth in SEQ ID NO:
- (GYTFTSYY), a CDR H2 comprising the amino acid sequence set forth in SEQ ID NO:2 (IYPGNVNT), a CDR H3 comprising the amino acid sequence set forth in SEQ ID NO:3 (ARTYFDY), a CDR L1 comprising the amino acid sequence set forth in SEQ ID NO:4 (SSVSY), a CDR L2 comprising the amino acid sequence set forth in SEQ ID NO:5 (DTS), and a CDR3 L3 comprising the amino acid sequence set forth in SEQ ID NO:6 (QQWSSKSFT.)
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An antibody or antigen-binding fragment thereof that specifically binds to human TTR, wherein the antibody or antigen-binding fragment thereof comprises the CDR H1, CDR H2, CDR H3, CDR L1, CDRL2, and CDR L3 of the antibody produced by the hybridoma of ATCC® deposit number PTA-125005.
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A method for testing the activity of a TTR-binding compound comprising administering the TTR-binding compound and TTR fibrils to a rodent.
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Dependencies are inferred from the claim text.