Multivalent pharmacophores for high avidity and overexpressed-target specific binding and uses thereof

Abstract

Overexpression of a variety of cell surface markers in cancer cells and/or non-cancer cells in the tumor microenvironment is an important hallmark for many types of cancers and is associated with cancer progression and poor prognosis. This invention provides multivalent pharmacophores for high avidity and specific binding to these overexpressed markers with much reduced binding to normally-expressed targets in healthy tissues. Further, the pharmacophores will not be interfered by soluble targets present in the circulatory systems and in tumor microenvironment. This new class of targeting therapeutics and diagnostics will provide better efficacy in cancer treatment and higher accuracy in cancer diagnosis than the currently available therapeutic and diagnostic means. This invention will also expand the range of targets that can be targeted in both cancer treatment and diagnosis, and more types of cancers can be treated target-specifically. Other diseases that have overexpressed cell surface markers in diseased cells will also be benefitted from this invention.

Dependencies are inferred from the claim text.