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US 2021/0230244 A1Published application
Peptide complex with immunodulatory and anti-inflammatory function
AssigneeNational Institute of Immunology
InventorsSarika GUPTA, Viji VIJAYAN
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Abstract
The present invention relates to compositions that are effective in management of inflammatory diseases. The disclosure provides a peptide complex comprising Abeta 1-42 and undercarboxylated osteocalcin which displays anti-inflammatory and immunomodulatory functions. The disclosure further provides with processes for preparing the compositions.
Claims18
A peptide complex comprising Abeta 1-42 peptide and undercarboxylated osteocalcin (Glu-OC) for modulating inflammation, wherein Abeta 1-42 peptide is represented by SEQ ID NO:
- 1, and undercarboxylated osteocalcin is represented by SEQ ID NO:
- 2.
A method of identifying a compound for immunomodulation, said method comprising;
- (a) obtaining Abeta 1-42 peptide;
- (b) contacting the Abeta 1-42 peptide with a compound comprising undercarboxylated glutamic acid residues having a lower concentration as compared to concentration of Abeta 1-42 peptide to form a complex;
- wherein the complex reduces the toxicity of Abeta 1-42 and (c) evaluating the complex for immunomodulation where activity of an innate immune cell like monocyte and macrophage is altered.
Dependencies are inferred from the claim text.