Modified natural killer cells and natural killer cell lines having increased cytotoxicity
AssigneeOnk Therapeutics Limited
InventorMichael Eamon Peter O'DWYER
Life of this patent
Estimating the term…
Abstract
NK cells and NK cell lines are modified to increase cytotoxicity, wherein the cells and compositions thereof have a use in the treatment of cancer. Production of modified NK cells and NK cell lines is via genetic modification to add mutant (variant) TRAIL ligand expression.
Claims21
1-20. (canceled)
A human natural killer (NK) cell or NK cell line modified to express a TRAIL mutant, wherein the TRAIL mutant has an increased affinity for a TRAIL receptor and/or a decreased affinity for a decoy TRAIL receptor, relative to wildtype TRAIL.
A natural killer (NK) cell or NK cell line that is genetically modified to express a TRAIL mutant, wherein the TRAIL mutant has an increased affinity for the DR5 receptor, relative to wildtype TRAIL.
A natural killer (NK) cell or NK cell line that is genetically modified to express a TRAIL mutant, wherein the TRAIL mutant has an increased affinity for the DR4 receptor, relative to wildtype TRAIL.
Dependencies are inferred from the claim text.