Methods for treating myelodysplastic syndromes and sideroblastic anemias
AssigneeAcceleron Pharma Inc.
InventorsKenneth M. Attie, Christopher Robert Rovaldi
Life of this patent
Estimating the term…
Abstract
In certain aspects, the present disclosure provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans. In some embodiments, the compositions of the disclosure may be used to treat or prevent sideroblastic anemias and myelodysplastic syndromes or one or more complications associated sideroblastic anemias and myelodysplastic syndromes.
Claims17
1-64. (canceled)
A method for treating or preventing a bone marrow disorder in a subject, comprising administering to a subject in need thereof an effective amount of an ActRII antagonist, wherein the subject has bone marrow cells that test positive for one or more mutations in a gene selected from the group consisting of:
- SF3B1, DNMT3A, and TET2.
66-174. (canceled)
188-195. (canceled)
Dependencies are inferred from the claim text.