Methods and compositions for treating inflammation

A method for treating inflammation in the gastrointestinal (GI) tract of a patient in need thereof comprising parenterally administering to the patient an effective amount of a nanoparticle composition, wherein the composition does not comprise an adjuvant, wherein the composition comprises a plurality of nanoparticle cores, each nanoparticle core coupled to a plurality of peptide antigen-MHC complexes, wherein:

• the peptide antigen comprises an epitope of the peptide having at least 80% identity to the peptide sequence of SEQ ID No. 2;
• the nanoparticle core has a diameter from about 1 nm to about 100 nm;
• and
• the ratio of peptide antigen-MHC complexes per nanoparticle core is from about 10:1 to about 1000:1;
• and
• the peptide antigen is a T cell epitope.