Proteins for the Treatment of Epithelial Barrier Function Disorders
AssigneeSecond Genome, Inc.
InventorsCristina N. Butterfield, Daniela Keilberg, Andrew W. Goodyear, Andrew W. Han
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Abstract
The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.
Claims19
A protein, comprising:
- an amino acid sequence having at least about 90% sequence identity to SEQ ID NO:
- 34.
Dependencies are inferred from the claim text.