Variant adeno-associated viruses and methods of using
AssigneesHoward Hughes Medical Institute, The Regents of the University of California
InventorsJoshua Dudman, Adam Hantman, Bum-Yeol Hwang, Alla Karpova, Loren Looger, Kimberly Ritola, David Schaffer, Dougal Gowanlock Robinson Tervo, Sarada Viswanathan
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Abstract
The present disclosure provides AAV variants that exhibit a preference for retrograde movement in neurons and methods of using such variants.
Claims19
-19. (canceled)
An adeno-associated virus 2 (AAV2) VP1 capsid protein comprising an amino acid sequence comprising SEQ ID NOs:82, 85, or 86 is inserted between amino acids N587 and R588 of the AAV2 VP1 capsid protein.
An AAV2 VP1 capsid protein comprising an amino acid sequence comprising sequence LAxxDxTKxA (SEQ ID NO:106), wherein the amino acid sequence is inserted between amino acids N587 and R588 of the AAV2 VP1 capsid protein and wherein the AAV2 VP1 capsid protein comprises an N382D and an V708I amino acid substitution.
Dependencies are inferred from the claim text.