Soluble Forms of Hendra and Nipah Virus G Glycoprotein
AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsChristopher C. Broder, Katharine N. Bossart
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Abstract
This invention relates to soluble forms of G glycoprotein from Hendra and Nipah virus. In particular, this invention relates to compositions comprising soluble forms of G glycoprotein from Hendra and Nipah virus and also to diagnostic and therapeutic methods using the soluble forms of G glycoprotein from Hendra and Nipah virus. Further, the invention relates to therapeutic antibodies including neutralizing antibodies, and vaccines for the prevention and treatment of infection by Hendra and Nipah viruses.
Claims4
1-40. (canceled)
A monoclonal antibody specifically reactive to a polypeptide comprising a soluble form of the ectodomain of Nipah virus G protein.
A vaccine for preventing or treating infection of a patient by Nipah virus comprising the antibody of claim 1.
A method of detecting infection by a Hendra virus comprising detecting Nipah virus antigens or antibodies to Nipah virus in a sample obtained from a subject suspected of being infected using the monoclonal antibody of claim 1.
Dependencies are inferred from the claim text.