Amp-activated protein kinase activating compounds and uses thereof

A compound of Formula (I):

• wherein:
• R1 is selected from:
• (a) C1-C6 alkyl substituted with one or more groups selected from list X;
• (b) Q;
• and
• (c) -L-Q;
• R2 is selected from:
• (a) H;
• (b) Q;
• and
• (c) -L-Q;
• and
• Q is independently selected at each occurrence and represents a ring selected from phenyl and a 5-6 membered heteroaryl containing one to three heteroatoms selected from N, O and S as ring members, and each Q is optionally substituted with one to three groups selected from List M;
• L is C1-C4 alkylene optionally substituted with one or two groups selected from halo, oxo (═O), —OH, C1-C2 haloalkyl, C1-C2 alkoxy, C1-C2 haloalkoxy, CN, COOR7, —OC(═O)R7, and NR8R9;
• R3 is H or —C(═O)—R6;
• R4 is H or —C(═O)—R6;
• R6 is H or C1-C6 alkyl that is optionally substituted with one to three groups selected from halo, CN, hydroxy, C1-C4 alkoxy, C1-C4 haloalkyl, —NR8R9, —OC(═O)—R7, and COOR7;
• R7 is independently selected at each occurrence from H and C1-C6 alkyl optionally substituted with up to three groups selected from halo, CN, hydroxy, C1-C4 alkoxy, and C1-C4 haloalkyl;
• R8 and R9 are each independently selected at each occurrence from H and C1-C4 alkyl optionally substituted with one or two groups selected from List X;
• or R8 and R9 taken together with the Nitrogen to which both are attached form a 5-6 membered heterocyclic ring optionally containing an additional heteroatom selected from N, O and S as a ring member, and optionally substituted with one to four groups selected from halo, oxo, C1-C2 alkyl, hydroxy, C1-C2 alkoxy, CN, and COOR7;
• R10 is independently at each occurrence C1-C6 alkyl optionally substituted with up to three groups selected from halo, CN, hydroxy, C1-C4 alkoxy, and C1-C4 haloalkyl;
• List X consists of halo, CN, —OH, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, ═O, —COOR7, —OC(═O)R7, —O—COOR10, —SO2R10, —SO2NR8R9, —O-Q, and —O-L-Q;
• List M consists of halo, CN, NO2, COOR7, CONR8R9, —SO2R10, —SO2NR8R9, C1-C2 haloalkyl, C1-C2 haloalkoxy, C1-C2 alkoxy, and C1-C2 alkyl;
• or a pharmaceutically acceptable salt thereof.