Novel all-trans polyene amphoteric macrolide
AssigneeDsm IP Assets B.V.
InventorsAlexander Lucia Leonardus DUCHATEAU, Peter Philip LANKHORST, Willebrordus Bernardus VAN SCHEPPINGEN
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Abstract
The present invention is directed to a process for purifying natamycin, to an all-trans polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide.
Claims13
A process for purifying natamycin comprising mixing a composition comprising crude natamycin, a metal salt of a carboxylic acid and water and subjecting the resulting mixture to chromatography whereby fractions are collected and selected fractions that comprise natamycin are combined, wherein the amount of said crude natamycin is from 1 g to 100 g/kg of the total weight of said composition and wherein the concentration of said metal salt of a carboxylic acid is from 0.1 mol/L to 5 mol/L.
A compound comprising (1R,3S,5E,7R,11R,13E,15E,17E,19E,21R,23S,24R,25S)-21-[(3-Amino-3,6-dideoxy-β-d-mannopyranosyl)oxy]-1,3,7,25-tetrahydroxy-11-methyl-9-oxo-10,27-dioxabicyclo[21.3.1]-heptacosa-5,13,15,17,19-pentaene-24-carboxylic acid of formula (II) or a salt thereof.
Dependencies are inferred from the claim text.