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US 2021/0230192 A1Published application
Method for preparing 18f-bpa and intermediate
AssigneeNeuboron Medtech Ltd.
InventorsShi-hong LI, Jing HE, Heng YAN, Fei CAI
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Abstract
A method for preparing 18F-BPA and an intermediate, by which high-purity 18F-BPA is obtained. The method simplifies the synthesis steps after 18F labeling, and is easy to operate and efficient.
Claims20
A method for preparing 18F-BPA with the structure:
- comprising using intermediate I with the structure
- where R1 or R2 represents halogens, boric acid groups or substituents that are hydrolyzable to boric acid groups;
- R3 or R4 independently represents hydrogen, an amino-protecting group, or an imino group combined with an amino group for protecting the amino group;
- and
- R5 represents hydrogen or a carboxyl-protecting group.
2 more elements
An intermediate I, having the structure
- where R1 or R2 represents halogens, boric acid groups or substituents that is hydrolyzable to boric acid groups;
- R3 or R4 independently represents hydrogen, an amino-protecting group, or an imino group combined with an amino group for protecting the amino group;
- and
- R5 represents hydrogen or a carboxyl-protecting group.
1 more element
Dependencies are inferred from the claim text.