Process for preparing substituted polycyclic pyridone derivative and crystal thereof
AssigneeShionogi & Co., Ltd.
InventorsSetsuya SHIBAHARA, Nobuaki FUKUI, Toshikatsu MAKI, Kosuke ANAN
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Abstract
The present invention provides a process for preparing a compound of the formula (II): wherein R2 is unsubstituted alkyl, characterized by reacting a compound of the formula (I): wherein R1 is hydrogen or a protecting group other than unsubstituted alkyl, with a compound of the formula: R2—OH, wherein R2 is as defined above, in the presence of a sodium salt and/or a magnesium salt.
Claims15
A process for preparing a compound of the formula (II):
- wherein R2 is unsubstituted alkyl;
- characterized by reacting a compound of the formula (I):
- wherein R1 is hydrogen or a protecting group other than unsubstituted alkyl, with a compound of the formula:
- R2—OH, wherein R2 is as defined above, in the presence of a sodium salt and/or a magnesium salt.
A process for preparing a compound of the formula (IV):
- wherein R3, R4, R5 and R6 are each independently hydrogen or halogen, provided that one or two of R3, R4, R5 and R6 is halogen;
- characterized by reacting a compound of the formula (II′):
- with a compound of the formula (III):
- wherein R3, R4, R5 and R6 are as defined above.
A compound of the formula (II′):
- or a salt thereof.
A compound of the formula (IV′):
- or a salt thereof.
A crystal of the compound of the formula (V):
- or a crystal of a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.