Positive allosteric modulators of the muscarinic acetylcholine receptor m1

A compound of formula (I),

• or a pharmaceutically acceptable salt thereof, wherein
• X is CR3a or N;
• Y is CR3b or N;
• Z is S, O, or NR4;
• L is —[C(RaRb)]p—, C2-C6-alkenylenyl, C(O), O, or S;
• A1 is Cyc1 or Cyc2-Q-Cyc3;
• R1 is hydrogen, alkyl, alkoxy, alkoxyalkyl, halogen, cyano, or haloalkyl;
• R2 is hydrogen, alkyl or haloalkyl;
• M is a bond, C2-C6-alkenylenyl, or —[C(RcRd)]t—[C(ReRf)]k—;
• A2 is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl;
• or A2 and R2, together with the atoms to which they are attached, form a heterocycle;
• R3a and R3b are each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen;
• R4 is hydrogen, or alkyl;
• R5 is independently, at each occurrence, hydrogen, alkyl, or —C(O)Rg;
• Cyc1 is aryl, heteroaryl, heterocycle or cycloalkyl;
• Cyc2 is aryl, heteroaryl, heterocycle or cycloalkyl;
• Q is a bond, C1-C6-alkylenyl, C2-C6-alkenylenyl, C(O)NH, O, S, or NR5;
• Cyc3 is aryl, heteroaryl, heterocycle or cycloalkyl;
• Ra, Rb, Rc, Rd, Re, and Rf are each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen;
• p is 0, 1, 2, 3, 4, 5, or 6;
• t is 0, 1, 2, or 3;
• k is 0, 1, 2, or 3;
• and
• Rg is independently, at each occurrence, alkyl, aryl, heteroaryl, cycloalkyl or alkoxy;
• wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.