Modulators of ion channel receptors and uses thereof
AssigneeBionomics Limited
InventorsBelinda HUFF, Courtney HOLLIS, Hamish TOOP, Nathan KUCHEL, Lorna Helen MITCHELL, Rajinder SINGH
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Abstract
Compounds useful in the modulation of ion channel activity in cells are disclosed herein. This disclosure also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.
Claims22
A compound of formula (I)
- or a salt, stereoisomer, solvate or prodrug thereof,
- wherein:
- R is an optionally substituted aryl, optionally substituted heterocycyl or optionally substituted heteroaryl;
- R1 is H or an optionally substituted C1-C4 alkyl;
- R2, R3, R4 and R5 are independently H or a C1-C4 alkyl or R2 and R3, or R4 and R5 together form a cycloalkyl ring;
- Y is selected from
- X is CH or N;
- and
- Z is H, F or CF3.
(canceled)
A method of treating or preventing pain disorders, said method including the step of administering to a patient a compound of formula (I)
- or a salts, stereoisomers, solvates or prodrugs thereof,
- wherein:
- R is an optionally substituted aryl, optionally substituted heterocycyl or optionally substituted heteroaryl;
- R1 is H or an optionally substituted C1-C4 alkyl;
- R2, R3, R4 and R5 are independently H or a C1-C4 alkyl or R2 and R3, or R4 and R5 together form a cycloalkyl ring;
- Y is selected from
- X is CH or N;
- and
- Z is H, F or CF3.
A method of manufacturing a medicament for treating or preventing pain disorders, said method comprising preparing a compound of formula (I)
- or a salts, stereoisomers, solvates or prodrugs thereof,
- wherein:
- R is an optionally substituted aryl, optionally substituted heterocycyl or optionally substituted heteroaryl;
- R1 is H or an optionally substituted C1-C4 alkyl;
- R2, R3, R4 and R5 are independently H or a C1-C4 alkyl or R2 and R3, or R4 and R5 together form a cycloalkyl ring;
- Y is selected from
- X is CH or N;
- and
- Z is H, F or CF3.
(canceled)
(canceled)
Dependencies are inferred from the claim text.