Imidaxopyrolone compound and application thereof

A compound represented by formula (I-1) or (I-2), or a pharmaceutically acceptable salt thereof,

• wherein
• is selected from a double bond and a single bond;
• in formula (I-1), ring A is selected from 5-membered heterocycloalkenyl, 5-membered heteroaryl and 5-membered heterocycloalkyl, wherein each the 5-membered heterocycloalkenyl, 5-membered heteroaryl and 5-membered heterocycloalkyl independently comprises 1 or 2 heteroatoms or heteroatomic groups independently selected from N, —NH—, —O—, —S—, —C(═O)—, —C(═S)—, —C(═O)O—, —S(═O)— and —S(═O)2—;
• provided that when ring A is selected from 5-membered heteroaryl, then the heteroatoms of the ring A do not simultaneously contain N and —O—;
• in formula (I-2), ring A is selected from 5-membered heterocycloalkenyl, 5-membered heteroaryl and 5-membered heterocycloalkyl;
• ring B is selected from 6-membered aryl and 6-membered heteroaryl;
• each X1 is selected from C, CH, C(R5) and N;
• each X2 is selected from C, CH, C(R9) and N;
• each X3 is selected from C, CH, C(R10) and N;
• each X4 is selected from C, CH, C(R11) and N;
• each X5 is selected from C, CH, C(R12) and N;
• each R1 is selected from H, C1-3 alkyl and C1-3 heteroalkyl, wherein the C1-3 alkyl and C1-3 heteroalkyl are each independently and optionally substituted with 1, 2 or 3 Ra;
• each R2 is selected from phenyl and 5-6 membered heteroaryl, wherein the phenyl and 5-6-membered heteroaryl are each independently and optionally substituted with 1, 2 or 3 Rb;
• R3 and R4 are each independently selected from H, halogen, OH, CN, NH2, C1-3 alkyl and C1-3 heteroalkyl, wherein the C1-3 alkyl and C1-3 heteroalkyl are each independently and optionally substituted with 1, 2 or 3 Rc;
• R5, R9, R10, R11 and R12 are each independently selected from halogen, OH, CN, NH2, C1-3 alkyl and C1-3 heteroalkyl, wherein the C1-3 alkyl and C1-3 heteroalkyl are each independently and optionally substituted with 1, 2 or 3 Rd;
• each R6 is selected from C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl, wherein the C1-6 alkyl, C1-6 heteroalkyl, C3-6 cycloalkyl and 3-6 membered heterocycloalkyl are each independently and optionally substituted with 1, 2 or 3 Re;
• R7 and R8 are each independently selected from C1-3 alkyl-O—, wherein the C1-3 alkyl-O— is optionally substituted with 1, 2 or 3 halogens;
• Ra, Rb, Rc, Rd and Re are each independently selected from halogen, OH, CN, NH2, C1-3 alkyl, C3-5 cycloalkyl and C1-3 heteroalkyl, wherein the C1-3 alkyl, C3-5 cycloalkyl and C1-3 heteroalkyl are each independently and optionally substituted with 1, 2 or 3 R;
• R is selected from F, Cl, Br, I, OH, CN, NH2, NO2, CH3, CH3CH2, CH3CH2CH2, (CH3)2CH, CF3, CHF2, CH2F and CH3O;
• each the 5-membered heterocycloalkenyl, 5-membered heteroaryl, 6-membered heteroaryl, 5-membered heterocycloalkyl, C1-3 heteroalkyl, C1-6 heteroalkyl, 5-6 membered heteroaryl and 3-6 membered heterocycloalkyl independently comprises 1, 2 or 3 heteroatoms or heteroatomic groups independently selected from N, —NH—, —O—, —S—, —C(═O)—, —C(═S)—, —C(═O)O—, —S(═O)— and —S(═O)2—.