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US 2021/0230158 A1Published application
INHIBITORS OF RORgamma
AssigneeVitae Pharmaceuticals, Inc.
InventorsRobert J. Duguid, John A. Grosso, Sergiy Krasutsky
Life of this patent
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Abstract
The present disclosure relates to processes for the production of salts and crystalline forms of a compound having the formula.
Claims20
A method of removing methyl bromide from a composition comprising methyl bromide and crystalline form D bis-hydrogen bromide salt of a compound having the following structural:
- comprising:
- i) slurrying the composition in a mixture of isopropyl acetate/water or a mixture of heptane/water;
- and
- ii) separating the crystalline form D bis-hydrogen bromide salt from the mixture of isopropyl acetate/water or the mixture of heptane/water.
1 more element
10-14. (canceled)
A method of forming a compound having the Formula:
- comprising the steps of
- i) reductively aminating an aldehyde compound represented by the following structural formula:
- with an amine compound represented by the following structural formula:
- wherein the reductive amination is carried out in the presence of an imine reducing agent;
- ii) quenching the reductive amination mixture with acid;
- iii) neutralizing the resulting solution with base, thereby precipitating the free base form of the compound;
- and
- iv) isolating the precipitated free-base form of the compound.
5 more elements
Dependencies are inferred from the claim text.