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US 2021/0230157 A1Published application
Pain treating compounds and uses thereof
OwnerBelinda HUFF, Courtney HOLLIS +8inventors
InventorsBelinda HUFF, Courtney HOLLIS, Hamish TOOP, Nathan KUCHEL, Lorna Helen MITCHELL, Rajinder SINGH, Thomas AVERY, Celine MICHAUT-SIMON, Jean-Marie CONTRERAS, Christophe MORICE
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Abstract
The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.
Claims17
A compound of formula (I)
- or a salt, stereoisomer, solvate, or prodrug thereof,
- wherein
- R is optionally substituted aryl, optionally substituted heterocycyl or optionally substituted heteroaryl;
- R1 is H or C1-C4 alkyl;
- R2, R3, R4 and R5 are independently H or C1-C4 alkyl or R2 and R3, or R4 and R5 together form a cycloalkyl ring;
- Y is selected from
- and
- X is CH or N.
5 more elements
A method of treating or preventing pain disorders, comprising, administering to a patient a compound of formula (I)
- or a salt, stereoisomer, solvate, or prodrug thereof, wherein
- R is optionally substituted aryl, optionally substituted heterocycyl or optionally substituted heteroaryl;
- R1 is H or optionally substituted C1-C4 alkyl;
- R2, R3, R4 and R5 are independently H or C1-C4 alkyl or R2 and R3, or R4 and R5 together form a cycloalkyl ring;
- Y is selected from
- and
- X is CH or N.
4 more elements
-19. (canceled)
Dependencies are inferred from the claim text.