Back to results
US 2021/0230153 A1Published application
Aryl hydrocarbon receptor (ahr) agonists and uses thereof
AssigneeIkena Oncology, Inc.
InventorsAlfredo C. Castro, Karen J. McGovern, Michael Burke
Life of this patent
Estimating the term…
Abstract
The present invention provides AHR agonists, compositions thereof, and methods of using the same.
Claims21
1-20. (canceled)
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Ring A is an optionally substituted 5-membered heteroaromatic ring having 1-3 heteroatoms independently selected from N, O, or S;
- Ring B is an optionally substituted ring selected from phenyl, a 6-membered heteroaromatic ring having 1-3 N, a 8-10 membered bicyclic aromatic ring, and a 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from N, O, or S;
- Ring C is optionally substituted phenyl or 6-membered heteroaromatic ring having 1-3 N;
- R11 is —R, —C(O)—RW, —C(═NRW)—RW, —S(O)2—RW, or —S(O)—RW;
- RW is —R, —N(R)2, —NR—OR, —N(R)—N(R)2, —N(OR)—N(R)2, —N(R)—N(OR)R, —OR, —O—N(R)2, or —SR;
- and
- R is hydrogen, optionally substituted C1-6 aliphatic, an optionally substituted 3-7 membered carbocyclic ring, or an optionally substituted 3-7 membered heterocyclic ring having 1-3 heteroatoms independently selected from N, O, or S, or two R's together with the nitrogen to which they attach form an optionally substituted 5-7 membered heterocyclic ring having 0-2 heteroatoms independently selected from N, O, or S in addition to the nitrogen to which the two R's attach,
- provided that the compound is not
6 more elements
A compound selected from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.