Arylnaphthalene compounds as vacuolar-atpase inhibitors and the use thereof
AssigneePurdue Research Foundation
InventorsVincent Jo Davisson, Aaron Raymond Lindstrom, Naoaki Fujii, Robert A. Davey
Life of this patent
Estimating the term…
Abstract
Ebola virus and Marburg virus are filoviruses and are responsible for outbreaks that cause up to 90% fatality, including the recent outbreak in West Africa that has resulted in over 11,000 deaths. The present disclosure generally relates to series novel arylnaphthalene compounds, having a formula (I) or a pharmaceutically acceptable salt thereof, as a vacuolar-ATPase inhibitor that are useful for the treatment for a broad spectrum of viral infections, including those infections caused by filoviruses. Pharmaceutical composition matters and methods of use are within the scope of this invention.
Claims20
A compound having a formula
- or a pharmaceutically acceptable salt thereof, wherein
- A is C═O, CR2, CH2, CHR, O, S, NH, NR, wherein R is an alkyl;
- B is hydrogen (H), deuterium (D), or fluorine (F);
- X is C═O, CR2, CH2, CHR, O, S, NH, NR, wherein R is an alkyl;
- Y is O, CF2, CH2, CHR, S, NH, NR, wherein R is an alkyl;
- R1 is hydrogen, an alkyl, alkylamide, alkenyl, alkenylamide, alkenylamino, alkynyl, alkynylamide, alkynylamino, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocyclyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, acyl, aryl, heteroaryl, arylalkyl, arylalkenyl, or arylalkynyl;
- and
- R2, R3, and R4 are each independently selected from the group consisting of hydrogen, deuterium, —CN, —CF3, and a halo.
A method for treating a patient with an infection, comprising the step of administering a therapeutically effective amount of one or more compounds, together with one or more carriers, diluents, or excipients, to a patient in need of relief from said infection, the compound having formula (I):
- or a pharmaceutically acceptable salt thereof, wherein
- A is C═O, CR2, CH2, CHR, O, S, NH, NR, wherein R is an alkyl;
- B is hydrogen (H), deuterium (D), or fluorine (F);
- X is C═O, CR2, CH2, CHR, O, S, NH, NR, wherein R is an alkyl;
- Y is O, CF2, CH2, CHR, S, NH, NR, wherein R is an alkyl;
- R1 is hydrogen, an alkyl, alkylamide, alkenyl, alkenylamide, alkenylamino, alkynyl, alkynylamide, alkynylamino, heteroalkyl, heteroalkenyl, heteroalkynyl, heterocycll, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, acyl, aryl, heteroaryl, arylalkyl, arylalkenyl, or arylalkynyl;
- and
- R2, R3, and R4 are each independently selected from the group consisting of hydrogen, deuterium, —CN, —CF3, and a halo.
Dependencies are inferred from the claim text.