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US 2021/0230103 A1Published application
Processes for preparing (e)-(2-(chloromethyl)-3-fluoroallyl) carbamate compounds
AssigneeYuhan Corporation
InventorsWoo Seob SHIN, Cheol Hee LIM
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Abstract
The present technology provides a process for selectively preparing an (E)-(2-(chloromethyl)-3-fluoroallyl)carbamate compound by refluxing an (E/Z)-(2-(chloromethyl)-3-fluoroallyl)carbamate compound in an organic solvent, followed by crystallization by cooling.
Claims9
A method of preparing a solid compound of Formula 1, the method comprising (a) refluxing a compound of Formula 1c in an organic solvent to form a reaction mixture;
- and (b) crystallizing the reaction mixture by cooling to less than 20° C. to obtain the solid compound of Formula 1,
- wherein Boc is a nitrogen protecting group.
A compound of Formula 1,
- wherein Boc is a nitrogen protecting group and the compound is a solid.
Dependencies are inferred from the claim text.