Microsphere for embolization, preparation method thereof, and method for embolizing tumor using the same

A method for preparing a microsphere, the method comprising:

• mixing a cross-linked hydrophilic substrate, a lipophilic substrate and a surfactant to obtain an emulsion, wherein the cross-linked hydrophilic substrate comprises cross-linked sodium alginate and gelatin;
• the lipophilic substrate comprises iodized oil, C16-C18 alkyl alcohol, and polycaprolactone;
• and the surfactant comprises polyoxyethylene stearate;
• and
• granulating the emulsion to obtain the microsphere.

A method for embolizing tumor in a subject, comprising:

• immersing a dry microsphere in a mixture to allow the dry microsphere to absorb the mixture and expand;
• and
• administering a therapeutically effective amount of the microsphere to the tumor,
• wherein the dry microsphere comprises a cross-linked hydrophilic substrate, a lipophilic substrate, and a surfactant;
• the cross-linked hydrophilic substrate comprises cross-linked sodium alginate and gelatin;
• the lipophilic substrate comprises iodized oil, C16-C18 alkyl alcohol, and polycaprolactone;
• and the surfactant comprises polyoxyethylene stearate.