Compositions for chelating metals at low temperatures
AssigneeUniversity of Iowa Research Foundation
InventorsMichael K. Schultz, Christopher Pigge, Mengshi Li, Moustafa Gabr, Edwin Sagastume
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Abstract
A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I): or a salt thereof wherein: each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa; each of R5-R12 is independently selected from the group consisting of H and -L-X; each Ra is independently selected from the group consisting of H and -L-X; each L is independently selected from the group consisting of absent and a linking group; and each X is a biological agent; and wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.
Claims30
A method of performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I):
- or a salt thereof wherein:
- each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa;
- each of R5-R12 is independently selected from the group consisting of H and -L-X;
- each Ra is independently selected from the group consisting of H and -L-X;
- each L is independently selected from the group consisting of absent and a linking group;
- and
- each X is a biological agent or ligand;
- and
- wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition.
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A method of diagnosing a disease in a patient in need thereof, comprising:
- (a) performing a chelating reaction comprising contacting a divalent metal with a compound of Formula (I):
- or a salt thereof wherein:
- each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa;
- each of R5-R12 is independently selected from the group consisting of H and -L-X;
- each Ra is independently selected from the group consisting of H and -L-X;
- each L is independently selected from the group consisting of absent and a linking group;
- and
- each X is a biological agent;
- and
- wherein the contacting occurs at a temperature below about 40° C. to form a chelated composition;
- and
- (b) administering the chelated composition to the patient within two hours of the chelating reaction.
A method of treating a disease in a patient in need thereof, comprising administering a chelated composition to the patient within two hours of the chelated composition being chelated, wherein the chelated composition comprises a compound of Formula I chelated with a divalent metal, wherein the compound of Formula I comprises:
- or a salt thereof wherein:
- each of R1-R4 is independently selected from the group consisting of CH2COORa and CH2C(═O)NHRa;
- each of R5-R12 is independently selected from the group consisting of H and -L-X;
- each Ra is independently selected from the group consisting of H and -L-X;
- each L is independently selected from the group consisting of absent and a linking group;
- and
- each X is a biological agent.
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Dependencies are inferred from the claim text.