Intranasal Delivery of Fluorescent Marker
AssigneeUCL Business PLC
InventorsBenjamin Michael Davis, Maria Francesca Corderio, Li Guo
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Abstract
The present invention provides a method of diagnosing a CNS disorder comprising administering a fluorescent marker of retinal integrity to a subject and generating an image of the subject's eye, wherein the fluorescent marker is delivered by intranasal administration is also provided and fluorescent markers of retinal integrity for use in such methods. Also provided is a pharmaceutical composition comprising an annex in or a functional fragment or derivative thereof conjugated to a compound of 2 kDa or less, wherein the composition comprises annex in or a functional fragment or derivative thereof conjugated at a concentration of at least mg/ml.
Claims34
A fluorescent marker of retinal integrity for use in diagnosing a CNS disorder, wherein the fluorescent marker is to be delivered by intranasal administration.
A fluorescent marker of retinal integrity for use according to any of claims to 1 to 15, wherein the CNS disorder is inflammatory (such as arthridides or granulomatous), infective (such as viral, encephalitic, or bacterial), vascular (such as angiogenic, occlusive or metabolic), or degenerative (such as glaucoma, age-related macular degeneration (AMD), Alzheimer's disease, or Parkinson's disease).
A method of diagnosing a CNS disorder comprising administering a fluorescent marker of retinal integrity to a subject and generating an image of the subject's eye, wherein the fluorescent marker is delivered by intranasal administration.
A method according to any of claims to 17 to 31, wherein the CNS disorder is inflammatory (such as arthridides or granulomatous), infective (such as viral, encephalitic, or bacterial), vascular (such as angiogenic, occlusive or metabolic), or degenerative (such as glaucoma, age-related macular degeneration (AMD), Alzheimer's disease, or Parkinson's disease).
A pharmaceutical composition comprising an annexin or a functional fragment or derivative thereof conjugated to a compound of 2 kDa or less, wherein the composition comprises annexin or a functional fragment or derivative thereof conjugated at a concentration of at least 5 mg/ml.
Dependencies are inferred from the claim text.