Zwitterionic biocompatible polymers, methods, and uses thereof

A biocompatible polymer, comprising:

• a polymer backbone comprising one or more repeating units, wherein the one or more repeating units are each individually selected from a zwitterionic precursor repeating unit of Formula (I):
• wherein R1 is —(CH2)n—, —(CH2)nO(CH2)m—, —(CH2CH2OCH2CH2)n—, —(CH2CH2O)nCH2CH2—, —(CH2CH2O)n(CH2)m—, —(CH2)n(CH2CH2O)m(CH2)p—, —((CH2)1-8C(O)O)n(CH2)m—, —((CH2)1-8C(O)O)n(CH2CH2O)m(OC(O)(CH2)1-8)p—, —((CH2)1-8C(O)O)n(CH2CH2)m(OC(O)(CH2)1-8)p—, —(CH2C(O)O)n(CH2CH2)m(OC(O)CH2)p—, —(CH(CH3)C(O)O)n(CH2CH2)m(OC(O)CH(CH3))p—, —(CH(CH3)C(O)O)n(CH2CH2)m(OC(O)CH(CH3))p—, —((CH2)nOC(O)O)(CH2CH2)m, —(CH2)nNHC(O)(CH2)m—, —(CH2)nC(O)NH(CH2)m, —(CH2)nS(O2)(CH2)m—, —(CH2)nS(O2)(CH2)mO(CH2)t—, —(CH2)nO—, —(CH2)nO(CH2)mO—, —(CH2CH2OCH2CH2)nO—, —(CH2CH2O)nCH2CH2O—, —(CH2CH2O)n(CH2)mO—, —(CH2)n(CH2CH2O)m(CH2)pO—, —((CH2)1-8C(O)O)n(CH2)mO—, —((CH2)1-8C(O)O)n(CH2CH2O)m(OC(O)(CH2)1-8)pO—, —((CH2)1-8C(O)O)n(CH2CH2)m(OC(O)(CH2)1-8)pO—, —(CH2C(O)O)n(CH2CH2)m(OC(O)CH2)pO—, —(CH(CH3)C(O)O)n(CH2CH2)m(OC(O)CH(CH3))pO—, —(CH(CH3)C(O)O)n(CH2CH2)m(OC(O)CH(CH3))pO—, —((CH2)nOC(O)O)(CH2CH2)mO—, —(CH2)nNHC(O)(CH2)mO—, —(CH2)nC(O)NH(CH2)mO—, —(CH2)nS(O2)(CH2)mO—, or —(CH2)nS(O2)(CH2)mO(CH2)tO—;
• R2 is C, P(OR7), or S(═O)
• R3 is O, NH, or OC(═O);
• R4, R5 and R7 are each independently H, —CH3, —(CH2)nCH3, —(CH2CH2O)nCH3, —(CH2CH2O)n(CH2)mCH3, —(CH2CH2O)n(CH2)mOH, —((CH2)nO)m((CH2)pO)q(CH2)rOH, —(CH2CH2O)nH, —(CH2)nOH, —(CH2)nO(CH2)mOH, —(CH2CH2OCH2CH2)nOH, —(CH2CH2O)nCH2CH2OH, —((CH2)1-8C(O)O)n(CH2)mOH, —((CH2)1-8C(O)O)n(CH2CH2O)m(OC(O)(CH2)1-8)pOH, —((CH2)1-8C(O)O)n(CH2CH2)m(OC(O)(CH2)1-8)pOH, —(CH2C(O)O)n(CH2CH2)m(OC(O)CH2)pOH, —(CH(CH3)C(O)O)n(CH2CH2)m(OC(O)CH(CH3))pOH, —((CH2)nOC(O)O)(CH2CH2)mOH, —(CH2)nNHC(O)(CH2)mOH, —(CH2)nC(O)NH(CH2)mOH, C1-n alkenyl, C1-n alkynyl, C6-10 aryl, pentafluorophenyl, or succinimidyl;
• R6 is F, Cl, Br, I, acetate, citrate, bicarbonate, carbonate, chlorate, dihydrogen phosphate, hydrogen phosphate, hydrogen sulfate, hydroxide, nitrate, nitride, nitrite, phosphate, sulfate, sulfide, sulfite, thiocyanate, thiosulfate, oxalate, perchlorate, chlorite, hypochlorite, periodate, iodate, hypoiodate, bromate, hypobromate, hypobromite, hydrogen carbonate, hydrogen sulfate, hydrogen sulfite, hydrogen oxalate, borate, tetraborate, hexfluorosilicate, tartrate, silicate, selenite, arsenate, ethanedioate, oxoethanoate, 2-hydroxyethanoate, propanoate, butanoate, pentanoate, butyrate, formate, lactate, maleate, oleate, oxalate, stearate, tarterate, urate, acrylate, glutamate, malonate, phthalate, barbiturate, cinnamate, hexanoate, folate, propionate, stearate, ascorbate, glutarate, azelate, benzilate, fumarate, gluconate, propiolate, tannate, gallate, titanate, trifluoroacetate, or diuranate;
• each n, m, p, q, and r is independently 1 to 10,000;
• and,
• t is 0 to 10,000.