Pathogen control compositions and uses thereof
AssigneeFlagship Pioneering Innovations VI, LLC
InventorsMaria Helena Christine VAN ROOIJEN, Barry Andrew MARTIN, Hok Hei TAM, Ignacio MARTINEZ, Nataliya Vladimirovna NUKOLOVA, Simon SCHWIZER, Daniel Garcia CABANILLAS
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Abstract
Disclosed herein are pathogen control compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are useful in methods for treating or preventing an infection in an animal and/or decreasing the fitness of pathogens (e.g., animal pathogens), or vectors thereof.
Claims99
A pathogen control composition comprising a plurality of PMPs, wherein each of the plurality of PMPs comprises a heterologous pathogen control agent and wherein the composition is formulated for delivery to an agricultural or veterinary animal pathogen or a vector thereof.
A pathogen control composition comprising a plurality of PMPs, wherein the PMPs are isolated from a plant by a process which comprises the steps of:
- (a) providing an initial sample from a plant, or a part thereof, wherein the plant or part thereof comprises EVs;
- (b) isolating a crude PMP fraction from the initial sample, wherein the crude PMP fraction has a decreased level of at least one contaminant or undesired component from the plant or part thereof relative to the level in the initial sample;
- (c) purifying the crude PMP fraction, thereby producing a plurality of pure PMPs, wherein the plurality of pure PMPs have a decreased level of at least one contaminant or undesired component from the plant or part thereof relative to the level in the crude EV fraction;
- (d) loading the plurality of PMPs of step (c) with a pathogen control agent;
- and
- (e) formulating the PMPs of step (d) for delivery to an agricultural or veterinary animal pathogen or a vector thereof.
A method of treating an animal having a fungal infection, wherein the method comprises administering to the animal an effective amount of a pathogen control composition comprising a plurality of PMPs.
A method of treating an animal having a fungal infection, wherein the method comprises administering to the animal an effective amount of a pathogen control composition comprising a plurality of PMPs, and wherein the plurality of PMPs comprises an antifungal agent.
A method of treating an animal having a bacterial infection, wherein the method comprises administering to the animal an effective amount of a pathogen control composition comprising a plurality of PMPs.
A method of treating an animal having a bacterial infection, wherein the method comprises administering to the animal an effective amount of a pathogen control composition comprising a plurality of PMPs, and wherein the plurality of PMPs comprises an antibacterial agent.
A method of decreasing the fitness of a parasitic insect, wherein the method comprises delivering to the parasitic insect a pathogen control composition comprising a plurality of PMPs.
A method of decreasing the fitness of a parasitic insect, wherein the method comprises delivering to the parasitic insect a pathogen control composition comprising a plurality of PMPs, and wherein the plurality of PMPs comprise an insecticidal agent.
A method of decreasing the fitness of a parasitic nematode, wherein the method comprises delivering to the parasitic nematode a pathogen control composition comprising a plurality of PMPs.
A method of decreasing the fitness of a parasitic nematode, wherein the method comprises delivering to the parasitic nematode a pathogen control composition comprising a plurality of PMPs, and wherein the plurality of PMPs comprises a nematicidal agent.
A method of decreasing the fitness of a parasitic protozoan, wherein the method comprises delivering to the parasitic protozoan a pathogen control composition comprising a plurality of PMPs.
A method of decreasing the fitness of a parasitic protozoan, wherein the method comprises delivering to the parasitic protozoan a pathogen control composition comprising a plurality of PMPs, and wherein the plurality of PMPs comprises an antiparasitic agent.
A method of decreasing the fitness of an insect vector of an animal pathogen, wherein the method comprises delivering to the vector a pathogen control composition comprising a plurality of PMPs.
A method of decreasing the fitness of an insect vector of an animal pathogen, wherein the method comprises delivering to the vector a pathogen control composition comprising a plurality of PMPs, and wherein the plurality of PMPs comprises an insecticidal agent.
Dependencies are inferred from the claim text.