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US 2021/0228708 A1Published application
Coronavirus vaccine formulations
AssigneeNovavax, Inc.
InventorsGale SMITH, Michael J. MASSARE, Jing-Hui TIAN
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Abstract
Disclosed herein are coronavirus Spike (S) proteins and nanoparticles comprising the same, which are suitable for use in vaccines. The nanoparticles present antigens from pathogens surrounded to and associated with a detergent core resulting in enhanced stability and good immunogenicity. Dosages, formulations, and methods for preparing the vaccines and nanoparticles are also disclosed.
Claims20
An immunogenic composition comprising:
- (i) a nanoparticle comprising a coronavirus S (CoV S) glycoprotein and a non-ionic detergent core, wherein the glycoprotein comprises a sequence that is at least 97% identical to SEQ ID NO:
- 2;
- and wherein amino acids 669-672 are QQAQ and amino acids 973 and 974 are P, wherein the amino acids are numbered with respect to SEQ ID NO:
- 2;
- (ii) a pharmaceutically acceptable buffer, and
- (iii) a saponin adjuvant.
3 more elements
Dependencies are inferred from the claim text.