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US 2021/0228652 A1Published application
Antimicrobial therapy
AssigneeThe Regents of the University of California
InventorsTeruaki Nakatsuji, Richard L. Gallo
Life of this patent
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Abstract
Methods and compositions comprising hogocidin peptides (SH-lantibiotics), derivatives and variants are provided. Also provided are methods and compositions comprising probiotic compositions utilizing strains of S. hominis and S. epidermidis that produce hogocidin, hogocidin-like peptides, or other inhibitors of skin pathogens. Methods of treatment for microbial skin infections and atopic dermatitis are also provided.
Claims20
A pharmaceutical composition, comprising:
- a peptide comprising the sequence of
- (SEQ ID NO:
- 56)
- KCSWWNASCHLGNNGKICTVSHECAAGCNL
- or
- (SEQ ID NO:
- 57)
- ATPTITTSSATCGGIIVAASAAQCPTLACSSRCGKRKK;
- and
- one or more pharmaceutical excipients.
7 more elements
A method of treating a skin disease or disorder, comprising:
- contacting a subject having a skin disease or disorder with an effective amount of a pharmaceutical composition comprising:
- a peptide comprising the sequence of
- (SEQ ID NO:
- 56)
- KCSWWNASCHLGNNGKICTVSHECAAGCNL
- or
- (SEQ ID NO:
- 57)
- ATPTITTSSATCGGIIVAASAAQCPTLACSSRCGKRKK;
- and
- one or more pharmaceutical excipients.
8 more elements
Dependencies are inferred from the claim text.