Treatments of prostate cancer
AssigneeThe Florida International University Board of Trustees
InventorsYUK-CHING TSE-DINH, YUAN LIU, IRINA AGOULNIK
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Abstract
The present invention provides compounds, compositions and methods for the treatment of prostate cancers, preferably, advanced prostate cancers. The subject invention also provides compounds, compositions and methods for preventing/slowing down/reducing the progress and proliferation of prostate cancer cells. The subject invention further provides compounds, compositions and methods for inhibiting DNA repair within cancer cells to slow tumor growth, preferably, by inhibiting BER capacity, including pol β and LIG I.
Claims20
A method for treating prostate cancer comprising administering to a subject in need of such treatment an effective amount of a pharmaceutical composition comprising one or more compounds selected from natamycin, calcipotriene, ceftazidime, nystatin, prasugrel, sirolimus, flecainide acetate, dihydroergotamine mesylate, risperidone, dipyridamole, doxycycline monohydrate, methylergonovine maleate, paliperidone, reserpine, and sunitinib malate.
A method for inhibiting/slowing down the progress and proliferation of prostate cancer cells comprising administering to a subject in need an effective amount of a pharmaceutical composition comprising one or more compounds selected from natamycin, calcipotriene, ceftazidime, nystatin, prasugrel, sirolimus, flecainide acetate, dihydroergotamine mesylate, risperidone, dipyridamole, doxycycline monohydrate, methylergonovine maleate, paliperidone, reserpine, and sunitinib malate.
A method for inhibiting DNA repair within prostate cancer cells comprising contacting prostate cancer cells with an amount of a pharmaceutical composition effective to inhibit DNA repair within prostate cancer cells, the pharmaceutical composition comprising natamycin.
Dependencies are inferred from the claim text.