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US 2021/0228607 A1Published application
Pharmaceutical composition for prevention or treatment of flavivirus infection
AssigneesLemonex Inc., Seoul National University R&Db Foundation
InventorsCheol Hee WON, Dal Hee MIN
Life of this patent
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Abstract
A method for treating a flavivirus infection includes administering to a subject in need thereof a composition which includes at least one of gentamicin sulfate, netilmicin, tobramycin, paromomycin, amikacin, capreomycin, trifluoperazine, dihydrostreptomycin, hydroxychloroquine, thioridazine HCl, efavirenz, miltefosine, nystatin, micafungin, bleomycin, resminostat, montelukast, norfloxacin, nedaplatin and cephalothin, which can exhibit excellent growth inhibition or killing effects of various species of flavivirus genus.
Claims9
1-8. (canceled)
9:
- A method for treating a flavivirus infection, the method comprising administering to a subject in need thereof a composition comprising:
- at least one of gentamicin sulfate, netilmicin, tobramycin, paromomycin, amikacin, capreomycin, trifluoperazine, dihydrostreptomycin, hydroxychloroquine, thioridazine HCl, efavirenz, miltefosine, nystatin, micafungin, bleomycin, resminostat, montelukast, norfloxacin, nedaplatin and cephalothin;
- or at least one of pharmaceutically acceptable salts of the above compounds.
10:
- The method of claim 9, wherein the flavivirus infection is at least one selected from the group consisting of an infection derived from Apoi virus, Aroa virus, Bagaza virus, Banzi virus, Bouboui virus, Bukarasa bat virus, Cacipacore virus, Carey Island virus, Cowbone Ridge virus, Dakar bat virus, dengue virus, Edge Hill virus, Entebbe bat virus, Gadgets Gully virus, Ilheus virus, Israel turkey meningoencephalomyelitis virus, Japanese encephalitis virus, Jugra virus, Jutiapa virus, Kadam virus, Kedougou virus, Kokobera virus, Koutango virus, Kyasanur Forest disease virus, Langat virus, Louping ill virus, Meaban virus, Modoc virus, Montana myotis leukoencephalitis virus, Murray Valley encephalitis virus, Ntaya virus, Omsk hemorrhagic fever virus, Phnom Penh bat virus, Powassan virus, Rio Bravo virus, Royal Farm virus, Saboya virus, Saint Louis encephalitis virus, Sal Vieja virus, San Perlita virus, Saumarez Reef virus, Sepik virus, Tembusu virus, Tick-borne encephalitis virus, Tyuleniy virus, Uganda S virus, Usutu virus, Wesselsbron virus, West Nile virus, Yaounde virus, Yellow fever virus, Yokose virus, Zika Virus and a combination thereof.
11:
- The method of claim 9, wherein the flavivirus infection is a dengue virus-derived infection.
12:
- The method of claim 9, wherein the composition further comprises at least one of tobramycin, trifluoperazine 2HCl, amikacin hydrate, hydroxychloroquine sulfate, thioridazine HCl, dihydrostreptomycin sulfate, gentamicin sulfate, netilmicin sulfate, capreomycin sulfate, paromomycin sulfate, resminostat, montelukast, norfloxacin, nedaplatin, bleomycin, nystatin, cephalothin, micafungin sodium, efavirenz and miltefosine;
- or at least one of pharmaceutically acceptable salts of the above compounds.
13:
- A method for inhibiting growth of flavivirus or killing the same, the method comprising administering to a subject in need thereof a composition comprising:
- at least one of gentamicin sulfate, netilmicin, tobramycin, paromomycin, amikacin, capreomycin, trifluoperazine, dihydrostreptomycin, hydroxychloroquine, thioridazine HCl, efavirenz, miltefosine, nystatin, micafungin, bleomycin, resminostat, montelukast, norfloxacin, nedaplatin and cephalothin;
- and at least one of pharmaceutically acceptable salts of the above compounds.
14:
- The method of claim 13, wherein the flavivirus is Apoi virus, Aroa virus, Bagaza virus, Banzi virus, Bouboui virus, Bukarasa bat virus, Cacipacore virus, Carey Island virus, Cowbone Ridge virus, Dakar bat virus, dengue virus, Edge Hill virus, Entebbe bat virus, Gadgets Gully virus, Ilheus virus, Israel turkey meningoencephalomyelitis virus, Japanese encephalitis virus, Jugra virus, Jutiapa virus, Kadam virus, Kedougou virus, Kokobera virus, Koutango virus, Kyasanur Forest disease virus, Langat virus, Louping ill virus, Meaban virus, Modoc virus, Montana myotis leukoencephalitis virus, Murray Valley encephalitis virus, Ntaya virus, Omsk hemorrhagic fever virus, Phnom Penh bat virus, Powassan virus, Rio Bravo virus, Royal Farm virus, Saboya virus, Saint Louis encephalitis virus, Sal Vieja virus, San Perlita virus, Saumarez Reef virus, Sepik virus, Tembusu virus, Tick-borne encephalitis virus, Tyuleniy virus, Uganda S virus, Usutu virus, Wesselsbron virus, West Nile virus, Yaounde virus, Yellow fever virus, Yokose virus, or Zika Virus.
15:
- The method of claim 13, wherein the flavivirus is dengue virus.
16:
- The method of claim 13, wherein the composition comprises at least one of tobramycin, trifluoperazine 2HCl, amikacin hydrate, hydroxychloroquine sulfate, thioridazine HCl, dihydrostreptomycin sulfate, gentamicin sulfate, netilmicin sulfate, capreomycin sulfate, paromomycin sulfate, resminostat, montelukast, norfloxacin, nedaplatin, bleomycin, nystatin, cephalothin, micafungin sodium, efavirenz and miltefosine;
- or at least one of pharmaceutically acceptable salts of the above compounds.