Use of nicotinamide riboside, nicotinic acid riboside, and nicotinamide mononucleotide, reduced nicotinyl compounds, and nicotinoyl compound derivatives in infant formula for healthy development
AssigneeChromaDex Inc.
InventorsRyan Dellinger, Troy Rhonemus, Mark Morris, Dietrich Conze, Amy Boileau
Life of this patent
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Abstract
Methods for delivering at least one compound selected from nicotinamide riboside (NR), nicotinic acid riboside (NAR), and nicotinamide mononucleotide (NMN), derivatives thereof, or salts thereof, in combination with at least one of thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), and pyridoxine (vitamin B6), to an infant human subject in need of said compound or compounds are provided.
Claims28
A method for delivering a nicotinyl riboside compound, or salt thereof, to an infant mammal subject, comprising the steps of:
- a. providing an infant formula composition comprising at least one nicotinyl riboside compound selected from the group consisting of nicotinamide riboside (NR, I), nicotinic acid riboside (NAR, II), reduced nicotinamide riboside (NRH, IV), reduced nicotinic acid riboside (NARH, V), nicotinamide riboside triacetate (NRTA, VI), nicotinic acid riboside triacetate (NARTA, VII), reduced nicotinamide riboside triacetate (NRH-TA, VIII), and reduced nicotinic acid riboside triacetate (NARH-TA, IX);
- and
- b. orally administering the infant formula composition to the infant mammal subject daily;
- wherein the amount of nicotinyl riboside compound in the infant formula composition is about 1,500 ug to about 10,000 ug per 100 kilocalories of the infant formula composition.
A method for delivering at least two nicotinyl riboside compounds, or salts thereof, to an infant mammal subject, comprising the steps of:
- a. providing an infant formula composition comprising at least one nicotinyl riboside compound selected from the group consisting of nicotinamide riboside (NR, I), nicotinic acid riboside (NAR, II), reduced nicotinamide riboside (NRH, IV), reduced nicotinic acid riboside (NARH, V), nicotinamide riboside triacetate (NRTA, VI), nicotinic acid riboside triacetate (NARTA, VII), reduced nicotinamide riboside triacetate (NRH-TA, VIII), and reduced nicotinic acid riboside triacetate (NARH-TA, IX);
- and
- b. orally administering the infant formula composition to the infant mammal subject daily.
An infant formula composition comprising at least one nicotinyl riboside compound, or salt thereof, selected from the group consisting of nicotinamide riboside (NR, I), nicotinic acid riboside (NAR, II), reduced nicotinamide riboside (NRH, IV), reduced nicotinic acid riboside (NARH, V), nicotinamide riboside triacetate (NRTA, VI), nicotinic acid riboside triacetate (NARTA, VII), reduced nicotinamide riboside triacetate (NRH-TA, VIII), and reduced nicotinic acid riboside triacetate (NARH-TA, IX);
- wherein the amount of nicotinyl riboside compound in the infant formula composition is about 1,500 ug to about 10,000 ug per 100 kilocalories of the infant formula composition.
An infant formula composition comprising at least one nicotinyl riboside compound, or salt thereof, selected from the group consisting of nicotinamide riboside (NR, I), nicotinic acid riboside (NAR, II), reduced nicotinamide riboside (NRH, IV), reduced nicotinic acid riboside (NARH, V), nicotinamide riboside triacetate (NRTA, VI), nicotinic acid riboside triacetate (NARTA, VII), reduced nicotinamide riboside triacetate (NRH-TA, VIII), and reduced nicotinic acid riboside triacetate (NARH-TA, IX);
- wherein said at least one nicotinyl riboside compound or salt thereof is a calcium, magnesium, potassium, sodium, zinc, N,N-dibenzylethylenediamine, chloroprocaine, choline, diethanolamine, ethylenediamine, meglumine (N-methylglucamine), tromethamine (tris(hydroxymethyl)aminomethane), procaine, fluoride, chloride, bromide, iodide, formate, acetate, ascorbate, benzoate, carbonate, citrate, carbamate, formate, gluconate, lactate, glycolate, malate, tartarate, glucuronate, maleate, fumarate, pyruvate, methane sulfonate, benzene sulfonate, p-toluenesulfonate, salicylate, galactarate, galacturonate, methyl bromide, methyl sulfate, nitrate, phosphate, diphosphate, succinate, sulfate, trifluoromethanesulfonate, trifluoroacetate, propionate, butyrate, glutamate, aspartate, tribromomethanesulfonate, trichloromethanesulfonate, or hydrogen carbonate salt.
A method for delivering a nicotinyl riboside compound, or salt thereof, to an infant mammal subject, comprising the steps of:
- a. providing an infant formula composition comprising at least one nicotinyl riboside compound selected from the group consisting of nicotinamide riboside (NR, I), nicotinic acid riboside (NAR, II), reduced nicotinamide riboside (NRH, IV), reduced nicotinic acid riboside (NARH, V), nicotinamide riboside triacetate (NRTA, VI), nicotinic acid riboside triacetate (NARTA, VII), reduced nicotinamide riboside triacetate (NRH-TA, VIII), and reduced nicotinic acid riboside triacetate (NARH-TA, IX);
- and
- b. orally administering the infant formula composition to the infant mammal subject daily;
- wherein the amount of nicotinyl riboside compound in the infant formula composition is about 1,500 ug to about 10,000 ug per 100 kilocalories of the infant formula composition;
- further wherein the level of fecal short chain fatty acid (SCFA) is increased.
Dependencies are inferred from the claim text.