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US 2021/0228601 A1Published application
Broad Spectrum Antiviral and Methods of Use
AssigneeThe Burlington Hc Research Group, Inc.
InventorsDale M. Walker, Adriana Elisa Kajon, Vernon E. Walker
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Abstract
A method for the prevention or treatment of Influenza virus infection or Adenovirus infection by administering an effective amount of a compound of Formula (I), Formula (II), or similar compound to an individual in need is provided.
Claims13
A method of treating a virus infection in an individual in need thereof, comprising:
- administering to the individual an effective antiviral amount of a compound or a pharmaceutically acceptable salt or solvate thereof, wherein the compound is of Formula (I) or Formula (II)
- wherein X is selected from the group consisting of —PO3H2, hydrogen, acetyl, isobutyryl, pivaloyl, and benzoyl,
- wherein each of R1, R2, and R3 is independently selected from hydrogen and C1-6 alkyl,
- wherein n is an integer of from 1 to 10, and
- wherein the virus is a DNA virus, an RNA virus, a DNA reverse transcribing virus or a non Retroviridae RNA reverse transcribing virus.
2 more elements
A method of treating a virus infection in an individual in need thereof, comprising:
- administering to the individual an effective antiviral amount of:
- (i) amifostine, the free thiol form of amifostine, the disulfide of amifostine (WR-33278), a combination of both the free thiol and the disulfide of amifostine, or other structurally and functionally related compounds;
- or
- (ii) phosphonol, the free thiol form of phosphonol, the disulfide of phosphonol, a combination of both the free thiol and the disulfide of phosphonol, or other structurally and functionally related compounds,
- wherein the virus is a DNA virus, an RNA virus, a DNA reverse transcribing virus, or a non Retroviridae RNA reverse transcribing virus.
2 more elements
(canceled)
A pharmaceutical kit comprising:
- a pharmaceutical composition comprising a compound or pharmaceutically acceptable salt or solvate thereof in a pharmaceutically acceptable carrier, the compound having Formula (I) or Formula (II):
- wherein X is selected from the group consisting of —PO3H2, hydrogen, acetyl, isobutyryl, pivaloyl, and benzoyl,
- wherein each of R1, R2, and R3 is independently selected from hydrogen and C1-6 alkyl, and
- wherein n is an integer of from 1 to 10;
- and
- directions for administering the pharmaceutical composition to a patient infected with a DNA virus, an RNA virus, a DNA reverse transcribing virus or a non Retroviridae RNA reverse transcribing virus.
3 more elements
Dependencies are inferred from the claim text.