Farnesoid x receptor modulators

A method of treating fibrosis or one or more symptoms of intrahepatic cholestasis or extrahepatic cholestasis in a subject in need thereof, comprising administering to the subject an effective amount of a compound of formula I:

• or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein:
• R1 is hydroxyl;
• R2 is hydrogen, hydroxyl, alkyl, or halogen, wherein said alkyl is unsubstituted or substituted with one or more Ra;
• R3 is hydrogen, hydroxyl, alkyl, or halogen, wherein said alkyl is unsubstituted or substituted with one or more Rb;
• R4 is alkyl, alkenyl, alkynyl, or halogen, wherein said alkyl is unsubstituted or substituted with one or more Rc;
• Ra, Rb, and Rc are each independently halogen or hydroxyl;
• R5 is hydroxyl, OSO3H, OSO3−, OCOCH3, OPO3H2, OPO32−, or hydrogen;
• and
• R6 is hydroxyl, OSO3H, OSO3−, OCOCH3, OPO3H2, OPO32−, or hydrogen;
• or taken together R5 and R6 with the carbon atom to which they are attached form a carbonyl.