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US 2021/0228591 A1Published application
Compositions and methods of use thereof for treatment of proteinopathies
AssigneeWashington University
InventorsStephen Pak, David Perlmutter, Gary Silverman
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Abstract
The present disclosure relates generally compositions and methods of using the same for the treatment of proteinopathies (e.g. Alpha-1-antitrypsin deficiency, Non-alcoholic fatty liver disease, Alzheimer's disease, Parkinson's disease, Amyotrophic Lateral Sclerosis, and Huntington's disease) with one or more proteotoxicity reducing agents.
Claims21
-35. (canceled)
A method for treating a subject having or suspected of having alpha-1-antitrypsin deficiency (ATD), the method comprising:
- administering to the subject a therapeutically effective amount of a composition comprising one or more of a proteotoxicity reducing agent selected from Tricyclic antipsychotics, Vasodilators, Antibiotics/Antiseptics, and Aryl piperazines.
A method for treating a subject having or suspected of a proteinopathy, the method comprising:
- administering to the subject a therapeutically effective amount of a composition comprising one or more of a proteotoxicity reducing agent selected from Tricyclic antipsychotics, Vasodilators, Antibiotics/Antiseptics, and Aryl piperazines.
Dependencies are inferred from the claim text.