Substituted cyclodextrin-metal complexes and uses thereof

A complex of a metal selected from the group comprising Ag, Zn, Cu, Pt, Au, oxides, hydroxides and salts thereof;

• with a cyclodextrin of formula (I)
• wherein:
• p is 6, 7 or 8;
• R is —OH or —X—NH—Z—NHR1;
• X is a single bond or R2;
• Z is selected from —C═O and —C═S;
• R1 is selected from H and optionally substituted short chain alkyls;
• R2 is selected from optionally substituted short chain alkyls;
• with the proviso that at least one R=—X—NH—Z—NHR1.

A method for preventing and/or treating skin infections, said method comprising administering to a subject in need thereof a therapeutically effective amount of:

• a complex of a metal selected from the group comprising Ag, Zn, Cu, Pt, Au, oxides, hydroxides and salts thereof;
• with a cyclodextrin of formula (I)
• wherein:
• p is 6, 7 or 8;
• R is —OH or —X—NH—Z—NHR1;
• X is a single bond or R2;
• Z is selected from —C═O and —C═S;
• R1 is selected from H and optionally substituted short chain alkyls;
• R2 is selected from optionally substituted short chain alkyls;
• with the proviso that at least one R=—X—NH—Z—NHR1;
• a composition comprising said complex;
• or
• a pharmaceutical composition comprising said complex in association with at least one therapeutically acceptable excipient.

A device selected from a wound dressing or a dermal patch, said device comprising

• a complex of a metal selected from the group comprising Ag, Zn, Cu, Pt, Au, oxides, hydroxides and salts thereof;
• with a cyclodextrin of formula (I)
• wherein:
• p is 6, 7 or 8;
• R is —OH or —X—NH—Z—NHR1;
• X is a single bond or R2;
• Z is selected from —C═O and —C═S;
• R1 is selected from H and optionally substituted short chain alkyls;
• R2 is selected from optionally substituted short chain alkyls;
• with the proviso that at least one R=—X—NH—Z—NHR1;
• a composition comprising said complex;
• or
• a pharmaceutical composition comprising said complex in association with at least one therapeutically acceptable excipient.

A method for improving the aqueous solubility of a metal selected from the group comprising Ag, Zn, Cu, Pt, Au, Ru, As, Sb, Bi, Ti, V, Ni, Hg, Pb, Co, oxides, hydroxides and salts thereof;

• wherein the method comprises providing a reaction mixture comprising said metal, an aqueous medium and a cyclodextrin of formula (I):
• wherein:
• p is 5, 6, 7 or 8;
• R is —OH or —X—NH—Z—NHR1
• X is a single bond or R2;
• Z is selected —C═O and —C═S;
• R1 is selected from H or optionally substituted short chain alkyls;
• preferably R1 is selected from methyl, ethyl and propyl;
• and
• R2 is selected optionally substituted short chain alkyls;
• preferably R1 is selected from methyl, ethyl and propyl;
• with the proviso that at least one R=—X—NH—Z—NHR1.