Methods of treating rbp4 related diseases with triazolopyridines
AssigneeBelite Bio, Inc
InventorsYu-Hsin Tom LIN, Cheng-Chi Irene WANG
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Abstract
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for the treatment of retinal binding protein (RBP4) related diseases, such as obesity and the like.
Claims19
A method of treating obesity in a subject in need thereof, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- each R1 is independently halogen, haloalkyl, or alkyl;
- R2 is —H, —OH, or halogen;
- p is 0, 1, 2, 3, 4, or 5;
- and
- A has the structure:
- wherein:
- α, β, χ, and δ are each independently absent or present, and when present each is a bond;
- X is N;
- Z1 is S, O, or N;
- Z2 is S, O, N, or NR3;
- R3 is H, C1-C4 alkyl, or oxetane;
- and
- B is a substituted or unsubstituted fused 5-, 6-, or 7-membered ring structure.
A method of treating obesity in a subject in need thereof, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a compound having the structure:
- or a pharmaceutically acceptable salt thereof.
A method of treating obesity in a subject in need thereof, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a compound having the structure:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.