Therapeutic agent for humoral immunity-related diseases in maternofetal relationship
OwnerKoushi YAMAGUCHIinventor
Life of this patent
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Abstract
A medicine for treating or ameliorating a disease associated with humoral immunity in the materno-fetal relationship, for example, sterility and infertility caused by humoral immunity in the materno-fetal relationship, blood type incompatible pregnancy, or fetal hemochromatosis, the medicine including, as an active ingredient, a compound selected from the group consisting of: (i) a compound represented by Formula (I) (wherein the respective reference numerals are as described in the specification) or a pharmaceutically acceptable salt thereof, (ii) a cyclosporine, and (iii) a rapamycin derivative.
Claims19
A medicine for treating a disease associated with humoral immunity in the materno-fetal relationship, the medicine comprising, as an active ingredient, a compound selected from the group consisting of:
- (i) a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof,
- wherein each of the adjacent pairs of R1 with R2, R3 with R4, and R5 with R6 each independently
- (a) represents two adjacent hydrogen atoms, or R2 may be an alkyl group, or
- (b) may form another bond between the carbon atoms to which the pair members are respectively bonded;
- R7 represents a hydrogen atom, a hydroxy group, or a protected hydroxy group, or may be bonded to R1 and together represent an oxo group;
- R8 and R9 independently represent a hydrogen atom or a hydroxy group;
- R10 represents a hydrogen atom, an alkyl group, an alkyl group substituted with one or more hydroxy groups, an alkenyl group, an alkenyl group substituted with one or more hydroxy groups, or an alkyl group substituted with an oxo group;
- X represents an oxo group, (a hydrogen atom, a hydroxy group), (a hydrogen atom, a hydrogen atom), or a group represented by formula:
- —CH2O—;
- Y represents an oxo group, (a hydrogen atom, a hydroxy group), (a hydrogen atom, a hydrogen atom), or a group represented by formula:
- N—NR11R12 or N—OR13;
- R11 and R12 independently represent a hydrogen atom, an alkyl group, an aryl group, or a tosyl group;
- R13, R14, R15, R16, R17, R18, R19, R22, and R23 independently represent a hydrogen atom or an alkyl group;
- R24 represents a ring which can include one or more heteroatoms and may be substituted as desired;
- n represents 1 or 2;
- and
- in addition to the meanings described above, Y, R10, and R23 may also be bonded together with the carbon atoms to which Y, R10, and R23 are bonded, and represent a heterocyclic group having a saturated or unsaturated, 5-membered or 6-membered ring and containing one or more heteroatoms selected from a nitrogen atom, a sulfur atom, and an oxygen atom, while the heterocyclic group may be substituted with one or more groups selected from an alkyl group, a hydroxy group, an alkyloxy group, a benzyl group, a group represented by formula:
- —CH2Se(C6H5), and an alkyl group substituted with one or more hydroxy groups,
- (ii) a cyclosporine, and
- (iii) rapamycin or a derivative thereof.
A method of treating a disease associated with humoral immunity in the materno-fetal relationship in a subject in need thereof, the method comprising administering to the subject an effective amount of a composition comprising, as an active ingredient, a compound selected from the group consisting of:
- (i) a compound of Formula (I) or a pharmaceutically acceptable salt thereof,
- wherein each of the adjacent pairs of R1 with R2, R3 with R4, and R5 with R6 each independently
- (a) represents two adjacent hydrogen atoms, or R2 may be an alkyl group, or
- (b) may form another bond between the carbon atoms to which the pair members are respectively bonded;
- R7 represents a hydrogen atom, a hydroxy group, or a protected hydroxy group, or may be bonded to R1 and together represent an oxo group;
- R8 and R9 independently represent a hydrogen atom or a hydroxy group;
- R10 represents a hydrogen atom, an alkyl group, an alkyl group substituted with one or more hydroxy groups, an alkenyl group, an alkenyl group substituted with one or more hydroxy groups, or an alkyl group substituted with an oxo group;
- X represents an oxo group, (a hydrogen atom, a hydroxy group), (a hydrogen atom, a hydrogen atom), or a group represented by formula:
- —CH2O—;
- Y represents an oxo group, (a hydrogen atom, a hydroxy group), (a hydrogen atom, a hydrogen atom), or a group represented by formula:
- N—NR11R12 or N—OR13;
- R11 and R12 independently represent a hydrogen atom, an alkyl group, an aryl group, or a tosyl group;
- R13, R14, R15, R16, R17, R18, R19, R22, and R23 independently represent a hydrogen atom or an alkyl group;
- R24 represents a ring which can include one or more heteroatoms and may be substituted as desired;
- n represents 1 or 2;
- and
- in addition to the meanings described above, Y, R10, and R23 may also be bonded together with the carbon atoms to which Y, R10, and R23 are bonded, and represent a heterocyclic group having a saturated or unsaturated, 5-membered or 6-membered ring and containing one or more heteroatoms selected from a nitrogen atom, a sulfur atom, and an oxygen atom, while the heterocyclic group may be substituted with one or more groups selected from an alkyl group, a hydroxy group, an alkyloxy group, a benzyl group, a group represented by formula:
- —CH2Se(C6H5), and an alkyl group substituted with one or more hydroxy groups,
- (ii) a cyclosporine, and
- (iii) rapamycin or a derivative thereof.
Dependencies are inferred from the claim text.