Taxane-lipid-polysaccharide dual conjugates, preparation methods thereof and uses thereof

A taxane-lipid-polysaccharide dual conjugate depicted by the formula (I):

• or a pharmaceutically acceptable salt or solvate thereof,
• within their structures:
• the so-called linker unit(s) may be selected from
• the polysaccharide is covalently linked to the linker unit(s) through one or more conjugation sites thereof;
• the linker unit is covalently linked to a taxane compound or a lipid compound unit;
• the polysaccharide conjugation site refers to a hydroxyl group, a carboxyl group, an amino group, a phosphate group or a sulfonic acid group inherent to the polysaccharide;
• the molecular molar ratio of the taxane compounds to the lipid compounds unit is an arbitrary ratio, preferably 0.1 to 99.9%, more preferably 0.1 to 60%, and far more preferably the following ratio range:
• 0.1 to 50, 0.1 to 20, 0.1 to 10, 0.1˜5, 0.1˜1, 1˜50, 1-20, 1˜10 or 1-5, such as 0.9, 0.8, 0.7, 0.6, 0.5, 0.4, 0.3, 0.2 or 0.1, or 9, 8, 7, 6, 5, 4, 3, 2 or 1;
• the polysaccharide is selected from phyto-polysaccharides, animal polysaccharides, microbial polysaccharides or synthetic polysaccharides and derivatives thereof;
• the taxane compound is selected from a natural or artificial semi-synthetic compound and a derivative thereof, which contains the core structure of taxane diterpenes;
• the lipid compound unit is a single molecular lipid compound, or a structural unit composed of a plurality of the same or of different single molecular of lipid compounds;
• the linker 1-3, the spacer 1-4, and the branching unit are all connected to each other by a covalent bond, and are also covalently bonded to the polysaccharide and the taxane compound;
• the covalent bond is selected from the group of bonds consisting of an amide bond, an amino-carbamate bond, an aminothiocarbamate bond, an ester bond, an isourea bond, a thiourea bond, a urea bond, a disulfide bond, a carbonate bond, a phosphate ester bond, phosphamide bond, sulfonamide bond, alpha or beta glycosylic bond, a covalent bond containing triazole.