Busulfan composition, preparation method therefor and application thereof
AssigneeJiangsu Linghang Biological Technology Co., Ltd.
InventorsGang WANG, Xiangyu DONG
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Abstract
Busulfan composition contains Busulfan and cyclodextrin in a weight ratio of 1-20:100-2000. The Busulfan composition is preferably prepared by following steps of: dissolving Busulfan in an organic solvent to obtain a Busulfan solution with a concentration of 1-20 mg/mL; dissolving SBE-β-cyclodextrin with water for injection to obtain 10-40% (w/v) aqueous solution of SBE-beta-cyclodextrin; mixing the two solutions under nitrogen atmosphere by stirring for 1 hour, and removing the organic solvent; and filtering and freeze drying the mixed solution. According to the present invention, the method can be used for tablets and injections.
Claims10
A Busulfan composition, containing:
- Busulfan and cyclodextrin in a weight ratio of 1-20:
- 100-2000, preferably 1:30-100, and more preferably 1:75.
Dependencies are inferred from the claim text.