High-Potency Vitamin C Topical Formulations
OwnerJihoon P. BAEKinventor
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Abstract
Topical formulations of L-ascorbic acid dissolved in a combination of a urea agent and a non-aqueous skin-compatible solvent are provided. The formulations are storage stable for an extended period of time without significant degradation of the L-ascorbic acid in the composition, are have desirable physical properties. The topical formulations can include high concentrations of the L-ascorbic acid. Topical compositions of this disclosure find use in treating or preventing a variety of cosmetic and/or dermatological conditions as well as to reduce the appearance of chronological and/or environmentally-caused skin aging.
Claims69
A storage stable topical composition comprising:
- a. 5% to 28% by weight ascorbic acid;
- b. 5% to 20% by weight of a urea agent;
- and
- c. less than 10% by weight in total of one or more optional additional components;
- d. dissolved in a non-aqueous skin-compatible solvent comprising polyol, C(1-6) alkanediol, glycol ether, dimethyl ether, or a combination thereof;
- wherein the ascorbic acid is dissolved at a concentration (AA) that is above its maximum concentration in the solvent alone (X), and the urea is dissolved at a concentration that is at least (AA−X)*1.25.
The composition of claim 26, wherein the composition comprises 2% or less by weight of the ferulic acid.
The composition of claim 26, wherein the composition comprises about 0.5% by weight of the ferulic acid.
The composition of any one of claims 16 and 26-28, wherein the composition comprises:
- 20% by weight ascorbic acid;
- 10% by weight urea agent;
- and
- a solvent that is 1,3-propanediol.
The composition of claim 30, wherein the composition comprises 3% to 10% by weight of the azelaic acid.
The composition of claim 31, wherein the composition comprises about 7.5% by weight of the azelaic acid
A process for stabilizing ascorbic acid for storage, the process comprising:
- combining:
- i. 1% to 20% by weight urea agent selected from urea, hydroxyethyl urea, and combination thereof;
- ii. 10% to 94% by weight of a non-aqueous skin-compatible solvent comprising C(3-6)polyol, ethoxydiglycol, dimethyl ether, or a combination thereof;
- and
- iii. optionally one or more additional agents;
- with
- iv. 5% to 28% by weight ascorbic acid;
- thereby dissolving the ascorbic acid to produce storage stable, nonaqueous, single-phase clear liquid composition of ascorbic acid.
Dependencies are inferred from the claim text.