Compounds for protection of cells

Compounds for use in treatment or prophylaxis of ischemic stroke, cerebral seizure, thrombosis, embolism, hemorrhage, cardiovascular disease, arthritis, diabetes, cancer, in particular cancer related to aging, atherosclerosis, heart failure, myocardial infarctions, schizophrenia, bipolar disorder, fragile X syndrome, sickle cell disease, and chronic fatigue syndrome, chronic obstructive pulmonary disease (COPD), a neurodegenerative disease such as Alzheimer disease, Parkinson disease, Lou Gehrig's disease, Huntington's disease, hypothermia/reperfusion, hemorrhagic shock, infection diseases involved in the attack or increased breakdown of thrombocytes, such as haemorhorragic fever, in particular ebola, Marburg disease and chagas wherein the compound has the structural formula of (I)

• wherein,
• R1, and R2 are independently selected from the group consisting of C1-C6 alkyl and is preferably methyl, ethyl, propyl or isopropyl;
• R3 is selected from the group consisting of —CH2OH, CH2NHR9, C(═O)YR10,
• where * indicates the point of attachment of R3 to the remainder of the molecule;
• R4, R5, R6, R7, R8 are independently selected from the group consisting of H, —OH, alkyl, substituted alkyl, preferably hydroxyalkyl, aryl, substituted aryl, halogen, oxygen, heteroaryl, substituted heteroaryl;
• X is selected from the group consisting of H, ═O, ═S;
• Y is selected from the group consisting of O, NH, S;
• R9 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, preferably hydroxyalkyl or substituted hydroxyalkyl, alkylbenzylfluoride, alkenyl, aryl, substituted aryl, preferably haloaryl, heteroaryl;
• R10 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, preferably hydroxyalkyl or cyanoalkyl, haloalkyl, alkylamide, substituted alkylamide, aryl, substituted aryl, preferably nitrobenzyl, halobenzyl, alkylbenzoyl, OH, alkenyl, alkadienyl, alkylhalide, arylhalide, —CH2(C═O)O-alkyl, heteroaryl, substituted heteroaryl, —NH—CH2CH2CN;
• R11 or R12, is alkyl, substituted alkyl, preferably an alkylamine, or form together with the atom N to which they are attached a saturated or unsaturated 3-8 membered ring, optionally incorporating one or more additional, such as one, two, or three N, O, or S atoms, optionally substituted with an alkyl, alkylalcohol;
• R13 and R14 together with the atom N to which they are attached form a saturated or unsaturated 3-8 membered ring, optionally incorporating one or more additional, such as one, two, or three N, O, or S atoms, optionally substituted, preferably with an alkyl, alkylalcohol.

Method for protection of cells comprising adding a compound to a cell, wherein the compound has the structural formula of (I)

• wherein,
• R1, and R2 are independently selected from the group consisting of C1-C6 alkyl and is preferably methyl, ethyl, propyl or isopropyl;
• R3 is selected from the group consisting of —CH2OH, CH2NHR9, C(═O)YR10,
• where * indicates the point of attachment of R3 to the remainder of the molecule;
• R4, R5, R6, R7, R8 are independently selected from the group consisting of H, —OH, alkyl, substituted alkyl, preferably hydroxyalkyl, aryl, substituted aryl, halogen, oxygen, heteroaryl, substituted heteroaryl;
• X is selected from the group consisting of H, O, S;
• Y is selected from the group consisting of O, NH, S;
• R9 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, preferably hydroxyalkyl or substituted hydroxyalkyl, alkylbenzylfluoride, alkenyl, aryl, substituted aryl, preferably haloaryl, heteroaryl;
• R10 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, preferably hydroxyalkyl or cyanoalkyl, haloalkyl, alkylamide, substituted alkylamide, aryl, substituted aryl, preferably nitrobenzyl, halobenzyl, alkylbenzoyl, OH, alkenyl, alkadienyl, alkylhalide, arylhalide, —CH2(C═O)O-alkyl, heteroaryl, substituted heteroaryl, —NH—CH2CH2CN;
• R11 or R12, alkyl, substituted alkyl, preferably an alkylamine, or form together with the atom N to which they are attached a saturated or unsaturated 3-8 membered ring, optionally incorporating one or more additional, such as one, two, or three N, O, or S atoms, optionally substituted with an alkyl, alkylalcohol;
• R13 and R14 together with the atom N to which they are attached form a saturated or unsaturated 3-8 membered ring, optionally incorporating one or more additional, such as one, two, or three N, O, or S atoms, optionally substituted, preferably with an alkyl, alkylalcohol.