Immuno-Oncology Compositions and Methods for Use Thereof
AssigneeGeoVax, Inc.
InventorFarshad Guirakhoo
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Abstract
The compositions and methods are described for generating an immune response to a tumor associated antigen such as MUC-1. The compositions and methods described herein relate to a modified vaccinia Ankara (MVA) vector encoding one or more viral antigens for generating a protective immune response to MUC-1 in the subject to which the vector is administered and boosting the immune response by administering a MUC-1 peptide. The compositions and methods of the present invention are useful both prophylactically and therapeutically and may be used to prevent and/or treat neoplasms and associated diseases.
Claims27
A immunogenic composition comprising:
- a) a recombinant modified vaccinia ankara (MVA) viral vector comprising a sequence encoding hypoglycosylated MUC-1 or fragment thereof and a matrix protein sequence, and
- b) a MUC-1 peptide.
A method of inducing an immune response in a subject in need thereof comprising a) administering at least one recombinant MVA vector expressing MUC-1 to the subject in an amount sufficient to induce an immune response, and administering at least one MUC-1 peptide to boost the induced immune response.
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A method of preventing or reducing the growth of a neoplasm comprising a) administering at least one recombinant MVA vector expressing MUC-1 to the subject in an amount sufficient to induce an immune response, and administering at least one MUC-1 peptide to boost the induced immune response.
A method of treating cancer comprising a) administering at least one recombinant MVA vector expressing MUC-1 to the subject in an amount sufficient to induce an immune response, and administering at least one MUC-1 peptide to boost the induced immune response.
Dependencies are inferred from the claim text.