Compositions and methods for treating gluten intolerance and disorders arising therefrom
AssigneeCodexis, Inc.
InventorsDavid C. Schriemer, Martial Rey
Life of this patent
Estimating the term…
Abstract
The invention described herein relates to methods and compositions for treatment of gluten intolerance and related conditions (e.g., celiac disease and gluten sensitivity), or inhibition of inflammation and/or immune response in the intestine due to antigenic food peptides, by administration of a pharmaceutical composition comprising one or more Nepenthes enzymes.
Claims17
A method for attenuating or preventing intestinal inflammation arising from the presence of peptidic food antigens in a patient in need thereof, which method comprises administering to the patient an effective amount of a pharmaceutical composition comprising an enzyme selected from the group consisting of nepenthesin I, nepenthesin II, neprosin, a variant thereof, and mixtures thereof, so as to cleave said antigens into non-antigenic peptides, thereby attenuating or preventing said intestinal inflammation.
-5. (canceled)
-8. (canceled)
A method for attenuating or preventing a manifestation of celiac disease arising from the presence of antigenic partially hydrolyzed wheat protein in an intestine of a patient having celiac disease, which method comprises administering to the patient an effective amount of an enzyme composition comprising an enzyme selected from the group consisting of nepenthesin I, nepenthesin II, neprosin, variant thereof, and a mixture thereof, so as to cleave said partially hydrolyzed wheat protein into non-antigenic peptides, thereby attenuating or preventing a manifestation of celiac disease.
A method for attenuating or preventing intraepithelial lymphocytosis due to the presence of peptidic food antigens in an intestine of a patient in need thereof, which method comprises administering to the patient an effective amount of enzyme pharmaceutical composition comprising an enzyme selected from the group consisting of nepenthesin I, nepenthesin II, neprosin, and mixtures thereof, under conditions wherein said antigens are degraded so as to attenuate or prevent intraepithelial lymphocytosis in the intestine.
19-46. (canceled)
A method for modulating celiac disease in a patient in need thereof, comprising administering to said patient an effective amount of a pharmaceutical composition comprising an enzyme selected from the group consisting of nepenthesin I, nepenthesin II, neprosin, a variant thereof, and mixtures thereof, so as to cleave said antigens into non-antigenic peptides, thereby modulating said celiac disease.
48-50. (canceled)
Dependencies are inferred from the claim text.