Substances Containing AuCs and Preparation Method and Use Thereof
AssigneeShenzhen Profound-View Pharma Tech Co., Ltd
InventorTaolei SUN
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Abstract
Disclosed are a pharmaceutical use of a gold cluster and a substance containing the gold cluster and the preparation method and use thereof. The gold cluster and substance containing the gold cluster can inhibit the aggregation of Aβ and α-syn, has excellent effects on the levels of cell models and animal models, and can be used to prepare drugs for preventing and treating Alzheimer's disease and/or Parkinson's disease.
Claims4
A method for treating a subject with Parkinson's disease, said method comprising:
- administrating a pharmaceutical composition into the subject with Parkinson's disease in an effective amount;
- wherein said pharmaceutical composition comprising a substance containing gold clusters (AuCs);
- wherein said substance comprises:
- AuCs;
- and
- a ligand Y coating the AuCs externally, wherein the ligand Y is a thiol-containing compound;
- wherein the AuCs have a gold core diameter smaller than 3 nm;
- wherein the thiol-containing compound is one selected from the group consisting of:
- L-cysteine, D-cysteine, N-acetyl-L-cysteine (L-NAC), N-acetyl-D-cysteine (D-NAC), L-cysteine-L-arginine dipeptide (CR), L-arginine-L-cysteine dipeptide (RC), L-histidine-L-cysteine dipeptide (HC), L-cysteine-L-histidine dipeptide (CH), glycine-L-cysteine-L-arginine tripeptide (GCR), L-proline-L-cysteine-L-arginine tripeptide (PCR), L-lysine-L-cysteine-L-proline tripeptide (KCP), L-glutathione (GSH), glycine-L-serine-L-cysteine-L-arginine tetrapeptide (GSCR), glycine-L-cysteine-L-serine-L-arginine tetrapeptide (GC SR), 1-[(2S)-2-methyl-β-thiol-1-oxopropyl]-L-proline, thioglycollic acid, mercaptoethanol, thiophenol, D-β-trolovol, N-(2-mercaptopropionyl)-glycine, and dodecyl mercaptan.
Use of a substance containing gold clusters (AuCs) for manufacture of a medicament for the treatment of Parkinson's disease in a subject, wherein said substance comprises:
- AuCs;
- and
- a ligand Y coating the AuCs externally, wherein the ligand Y is a thiol-containing compound;
- wherein the AuCs have a gold core diameter smaller than 3 nm;
- wherein the thiol-containing compound is one selected from the group consisting of:
- L-cysteine, D-cysteine, N-acetyl-L-cysteine (L-NAC), N-acetyl-D-cysteine (D-NAC), L-cysteine-L-arginine dipeptide (CR), L-arginine-L-cysteine dipeptide (RC), L-histidine-L-cysteine dipeptide (HC), L-cysteine-L-histidine dipeptide (CH), glycine-L-cysteine-L-arginine tripeptide (GCR), L-proline-L-cysteine-L-arginine tripeptide (PCR), L-lysine-L-cysteine-L-proline tripeptide (KCP), L-glutathione (GSH), glycine-L-serine-L-cysteine-L-arginine tetrapeptide (GSCR), glycine-L-cysteine-L-serine-L-arginine tetrapeptide (GC SR), 1-[(2S)-2-methyl-β-thiol-1-oxopropyl]-L-proline, thioglycollic acid, mercaptoethanol, thiophenol, D-β-trolovol, N-(2-mercaptopropionyl)-glycine, and dodecyl mercaptan.
Dependencies are inferred from the claim text.