Body Sculpting
AssigneeSculpt B.V.
InventorsThomas Cremers, Gunnar Flik, Henderik Willem Frijlink, Herman Johan Woerdenbag
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Abstract
The invention pertains to a pharmaceutical composition for topical administration, comprising a prodrug for an agonist and/or an antagonist for an adrenergic receptor, wherein the prodrug has an octanol/water partition coefficient of at least 0, for use in a method of shaping a mammalian body by modulation of subcutaneous fat tissue. The invention further pertains to cosmetic and therapeutic application of such prodrugs, such as their use in methods of shaping a mammalian body by locally modulating subcutaneous fat tissue. The invention also pertains to the prodrugs themselves, as well as to methods of making these prodrugs.
Claims28
A pharmaceutical composition for topical administration, comprising a prodrug for an agonist and/or an antagonist for an adrenergic receptor, which prodrug comprises said agonist or antagonist and a hydrolyzable moiety, wherein the prodrug has an octanol/water partition coefficient of at least 0, for use in a method of shaping a mammalian body by modulation of subcutaneous fat tissue.
A pharmaceutical composition according to any of the previous claims, further comprising a phosphodiesterase inhibitor and/or an adenyl cyclase stimulator.
A prodrug for an agonist and/or an antagonist for an adrenergic receptor, which prodrug comprises said agonist or antagonist and a hydrolyzable moiety, wherein the prodrug has an octanol/water partition coefficient of at least 0.
A method of making a prodrug for an adrenergic receptor agonist or antagonist, comprising esterifying an adrenergic receptor agonist or an adrenergic receptor antagonist with an acylating agent.
Dependencies are inferred from the claim text.