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US 2021/0214710 A1Published application
Light-inducible targeted modification of nucleic acids and genetic information
AssigneeFraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
InventorsStefan Schillberg, Gerda Noelke, Stefano Di Fiore
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Abstract
The technology provided herein pertains to methods for the modification of a target nucleic acid in vitro, ex vivo or in vivo in the genome of a cell by using a pre-assembled complex comprising a nucleic acid and a metal nanocluster and exposing the complex bound to a target nucleic acid to electromagnetic radiation.
Claims15
A method for the modification of a target nucleic acid in vitro, ex vivo or in vivo in the genome of a cell, the method comprising:
- (i) providing a target nucleic acid sequence to be modified;
- (ii) providing a pre-assembled complex comprising a nucleic acid and a metal nanocluster;
- (iii) binding the complex to the target nucleic acid;
- and
- (iv) inducing one or more single or double stranded nucleic acid breaks in the target nucleic acid by exposing the complex bound to the target nucleic acid to electromagnetic radiation.
2 more elements
Dependencies are inferred from the claim text.