Packaging for adhesive compositions
AssigneeAdhezion Biomedical, LLC
InventorsSheng ZHANG, Rafael RUIZ, Amanda GUIDO
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Abstract
A package system suitable for sterilizing cyanoacrylate compositions and providing the sterile cyanoacrylate compositions a shelf life of at least 24 months, wherein the package system comprises: an ampoule comprising a chamber comprising a cyanoacrylate monomer, wherein the chamber is defined by an opening and sidewalls, wherein the ampoule comprises a material comprising a cyclic olefin copolymer; a multilayer foil seal sealing the opening of the ampoule; and a secondary package housing the ampoule.
Claims16
A method for sterilizing cyanoacrylate compositions in a package system to provide sterile adhesive compositions with an extended shelf life of 2 years, wherein the method comprises:
- preparing a cyanoacrylate monomer composition with a purity of about 98% by weight, wherein the cyanoacrylate monomer composition is stabilized with at least one free radical and at least one anionic polymerization inhibitors, and wherein the cyanoacrylate monomer composition comprises at least one polymerization accelerator;
- adding the cyanoacrylate monomer composition into a primary package, wherein the primary package comprises a cyclic olefin copolymer;
- sterilizing the cyanoacrylate monomer composition via an irradiation method;
- assembling the primary package into an applicator having a tip and packing the applicator into a secondary package;
- and
- sterilizing the whole package system (e) via a chemical sterilization.
Dependencies are inferred from the claim text.