Affinity Reagent and Catalyst Discovery Through Fiber-Optic Array Scanning Technology
AssigneeSRI International
InventorsNathan Collins, Peter B. Madrid
Life of this patent
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Abstract
Devices, systems and methods for affinity reagent and catalyst discovery employing a library on a bead HTS platform, each bead comprising affixed non-natural polymers of a distinct bioactive monomer with sequence pre-defined branching and folding in tertiary structures, and fiber-optic array scanning technology.
Claims21
1-20. (canceled)
A dihydroisoquinolinone monomer selected from the group consisting of:
A polymer comprising residues of one or more monomers selected from the group consisting of:
The polymer of claim 0, comprising residues of two or more monomers selected from the group consisting of:
The polymer of claim 0, comprising residues of three or more monomers selected from the group consisting of:
The polymer of claim 0, comprising residues of four or more monomers selected from the group consisting of:
The polymer of claim 0, comprising residues of five or more monomers selected from the group consisting of:
A bead for high-throughput drug screening having affixed thereto the polymer of claim 0.
A fiber optic scanner mounted with a slide bearing the bead of claim 0.
A library of beads for high-throughput drug screening, each bead having affixed thereto the polymer of claim 0.
Dependencies are inferred from the claim text.